C. Luechtenborg

The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion

This study shows that Ebola virus VP40 matrix disassembles in endosomes due to pH changes, facilitating membrane fusion and viral entry.

The glycolipid GlcCer is recruited into the viral envelope to promote phenuivirus binding to host cells

This study identifies GlcCer as a viral glycolipid essential for phenuivirus binding to host cells, showing its role in viral attachment and receptor identification.

The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria

The paper identifies Cqd1 as a mitochondrial inner membrane protein that forms a novel contact site with outer membrane proteins Por1 and Om14, contributing to mitochondrial homeostasis.

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

The paper identifies an amphipathic α-helix in Apq12 that regulates NPC biogenesis by modulating Brl1 and Brr6 interactions and phosphatidic acid accumulation at the nuclear envelope.

Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme SQS

The paper shows that SPP cleaves SQS at high cholesterol levels, targeting it for degradation via TRC8, thereby regulating mevalonate pathway abundance.

Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.

Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex

The paper identifies Ice2 as a regulator of ER membrane biogenesis in yeast by inhibiting the Nem1-Spo7 complex and Pah1 phosphatase.

Oncogenic memory underlying minimal residual disease in breast cancer

This study identifies metabolic features of minimal residual disease (MRD) cells in breast cancer that resemble the tumor state, suggesting oncogenic memory and potential therapeutic targets.

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects

This study identifies Lancefield polysaccharides as critical for hGIIA to kill Group A and B Streptococcus by enabling penetration through the bacterial cell wall.