Author

T. Alexandrov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 3 Immunology· 2 Scientific Communication & Education· 1

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Research Focus:cell type annotation· 7 Organism:human· 7 Approach:experimental assay· 6 Research Focus:differential expression· 4 Approach:statistical model· 4 Approach:deep learning· 3 Assay:spatial transcriptomics· 3 Research Focus:cell-cell communication· 2

Frequent Co-Authors

S. Triana· 4 shared M. L. Stanifer· 3 shared S. Boulant· 3 shared C. Kee· 2 shared P. Doldan· 2 shared A. Aksenov· 1 shared A. Bouslimani· 1 shared A. C. McAvoy· 1 shared

Activity by Year

2019-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

S. Triana

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A system-wide analysis of lipid transfer proteins delineates lipid mobility in human cells

K. Titeca, A. Chiapparino, D. Turei, J. Zukowska, L. van Ek, M. Moqadam, S. Triana, I. O. Nielsen, M. Moller Foged, C. Gehin, K. Maeda, T. Alexandrov, J. Saez-Rodriguez, N. Reuter, M. L. Hennrich, A.-C. Gavin

The paper identifies lipid cargoes for half of analyzed human LTPs, revealing selectivity for lipid head groups and acyl chains and new lipid-organelle relationships.

Nature · Jan 7, 2026Peer-reviewedBiochemistry

Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer cells

E. Buglakova, M. Ekelöf, M. Schwaiger-Haber, L. Schlicker, M. R. Molenaar, S. Mohammed, L. Stuart, A. Eisenbarth, V. Hilsenstein, G. Patti, A. Schulze, M. Snaebjornsson, T. Alexandrov

This paper introduces 13C-SpaceM, a method for spatial single-cell isotope tracing of de novo fatty acid synthesis in cancer cells, revealing metabolic heterogeneity in liver and glioma tissues.

bioRxiv · Aug 18, 2023 · PreprintBiochemistry

Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection

P. Laise, M. L. Stanifer, G. Bosker, X. Sun, S. Triana, P. Doldan, F. La Manna, M. De Menna, R. B. Realubit, S. Pampou, C. Karan, T. Alexandrov, M. Kruithof-de Julio, A. Califano, S. Boulant, M. J. Alvarez

This study identifies host cell master regulators affected by SARS-CoV-2 and develops a method to find drugs that reverse their inactivation without harming beneficial immune responses.

bioRxiv · Jul 3, 2021Microbiology

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

S. H. Triana, D. Vonficht, L. Jopp-Saile, S. Raffel, R. Lutz, D. R. Leonce, M. Antes, P. Hernandez-Malmierca, D. Ordonez-Rueda, B. Ramasz, T. Boch, J.-C. Jann, D. Nowak, W.-K. Hofmann, C. Muller-Tidow, , S. Haas

The paper generates single-cell proteo-genomic reference maps of human hematopoietic cells to enable precise cell state purification and functional profiling.

bioRxiv · Mar 18, 2021Immunology

Public LC-Orbitrap-MS/MS Spectral Library for Metabolite Identification

P. Phapale, A. Palmer, R. M. Gathungu, D. Kale, B. Brugger, T. Alexandrov

The paper constructs and shares an open LC-MS/MS spectral library with over 1600 fragmentation spectra for metabolite identification.

bioRxiv · Nov 21, 2020Biochemistry

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut

S. Triana, C. Metz Zumaran, C. Ramirez, C. Kee, P. Doldan, M. Shahraz, D. Schraivogel, A. R. Gschwind, L. M. Steinmetz, C. Herrmann, T. Alexandrov, S. Boulant, M. L. Stanifer

This study identifies enterocytes as the main target of SARS-CoV-2 in the gut and shows the virus suppresses interferon signaling to evade immune response.

bioRxiv · Oct 21, 2020Immunology

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project

T. M. El-Achkar, M. T. Eadon, R. Menon, B. B. Lake, T. K. Sigdel, T. Alexandrov, S. Parikh, G. Zhang, D. Dobi, K. W. Dunn, E. A. Otto, C. R. Anderton, J. M. Carson, J. Luo, C. Park, , For the Kidney Precision Medicine Project

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

bioRxiv · Aug 23, 2020 · PreprintScientific Communication & Education

Critical role of type III interferon in controlling SARS-CoV-2 infection, replication and spread in primary human intestinal epithelial cells

M. L. Stanifer, C. Kee, M. Cortese, S. triana, M. Mukenhirn, H.-G. Kraeusslich, T. Alexandrov, R. Bartenschlager, S. Boulant

This study shows that human intestinal epithelial cells support SARS-CoV-2 infection and replication, with type III interferon more effective than type I in controlling viral spread.

bioRxiv · Apr 24, 2020 · PreprintMicrobiology

The Molecular and Microbial Microenvironments in Chronically Diseased Lungs

N. Garg, A. V. Melnik, Y. Vasquez-Baeza, A. Aksenov, E. R. Hyde, A. C. McAvoy, M. Wang, R. da Silva, I. Protsyuk, J. V. Wu, A. Bouslimani, Y. W. Lim, T. Luzzatto-Knaan, W. Comstock, R. A. Quinn, , R. Knight

The paper generates 3D maps of microbiomes and metabolomes in cystic fibrosis lungs, revealing personalized and regiospecific chemical environments and microbial interactions.

bioRxiv · Jun 19, 2019 · PreprintMicrobiology