Author

D. Karagiannis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Lu· 3 shared X. Chen· 3 shared A. Califano· 1 shared A. E. Oro· 1 shared A. K. Rustgi· 1 shared A. Li· 1 shared A. Vasciaveo· 1 shared A. Zaika· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

C. Lu

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Author profile →

3 papers

Recent·Most cited

Cell BiologyScience AdvancesPeer-reviewedOct 11, 2024

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

Y. Zhang, D. Karagiannis, H. Liu…·J. Que

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

DOI 10.1126/sciadv.adq0479

mousehuman

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 18, 2023

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

J. J. Li, A. Vasciaveo, D. Karagiannis…·M. M. Shen

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

DOI 10.1101/2023.07.18.549585

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 24, 2023

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.

D. Karagiannis, W. Wu, A. Li…·C. Lu

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.

DOI 10.1101/2023.04.24.538118

humanChIP-seq

𝕏 PostBluesky