M. M. Shen

Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer

This study shows RA signaling promotes luminal identity in prostate progenitors through Foxa1, and identifies a loss-of-function mutation in Foxa1 linked to prostate cancer dedifferentiation.

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

This study uses scRNA-seq data from mouse and human prostate tissues to show epithelial plasticity in regression, regeneration, and cancer, with findings on cell type origins and AR signaling heterogeneity.

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells

The paper uses multi-omics single-cell data to define the epigenetic basis of castration-resistant prostate luminal cells in mice and identifies key molecular pathways involved.

OncoLoop: A network-based precision cancer medicine framework

OncoLoop predicts and validates drug sensitivity in tumors and their models by leveraging perturbational profiles of oncology drugs, showing success in prostate cancer models and patient cohorts.

Intra-epithelial non-canonical Activin A signalling safeguards prostate progenitor quiescence

This study identifies non-canonical Activin A signaling as a mechanism maintaining prostate epithelial progenitor quiescence, with implications for cancer and therapy.