Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner
P. Chawla, I. Sharma, D. Gau, I. Eder, F. Chen, V. Yu, N. Welling, D. Boone, J. Taboas, A. V. LEE, A. Larregina, D. L. Galson, P. Roy
This study shows that MRTF in breast cancer cells promotes osteoclast differentiation via paracrine signaling, enhancing bone metastasis, and suggests MRTF inhibition as a potential therapeutic strategy.
bioRxiv · Dec 6, 2023Cancer Biology