Author

D. L. Hartl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. I. Sharma· 1 shared A. N. Nguyen Ba· 1 shared A. Y. Burkhard· 1 shared B. C. Willett· 1 shared C. B. Ogbunugafor· 1 shared D. F. Wirth· 1 shared E. Hathaway· 1 shared E. I. Shakhnovich· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCell Biology

A. I. Sharma

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Artemisinin resistance mutations in Pfcoronin impede hemoglobin uptake

I. Ullah, M. A. Farringer, A. Y. Burkhard, E. Hathaway, M. Khushu, B. C. Willett, S. H. Shin, A. I. Sharma, M. C. Martin, K. L. Shao, J. D. Dvorin, D. L. Hartl, S. K. Volkman, S. Bopp, S. Absalon, D. F. Wirth

This study identifies Pfcoronin mutations as a mechanism of artemisinin resistance by impairing hemoglobin uptake in Plasmodium falciparum.

bioRxiv · Dec 22, 2023 · PreprintCell Biology

Switching an active site helix in dihydrofolate reductase reveals limits to sub-domain modularity

V. Y. Zhao, J. V. Rodrigues, E. R. Lozovsky, D. L. Hartl, E. I. Shakhnovich

This study replaces a helical segment in DHFR with sequences from unrelated proteins, showing that while chimeras fold, their activity and stability are reduced, highlighting limits to sub-domain modularity.

bioRxiv · Jun 18, 2021Biophysics

Experimental evolution for niche breadth in bacteriophage T4 highlights the importance of structural genes

J. Y. Pham, C. B. Ogbunugafor, A. N. Nguyen Ba, D. L. Hartl

This study uses experimental evolution of bacteriophage T4 in different host environments to show that structural genes are key determinants of niche breadth evolution.

bioRxiv · Jun 13, 2019Evolutionary Biology