C. B. Ogbunugafor

A phylogenetic approach to studying the roles of within-host evolution and between-host transmission of resistance for clinical Escherichia coli infections

This study uses phylogenetic methods to analyze how antibiotic resistance in E. coli evolves within hosts versus spreads between hosts for different antibiotics.

Environmental modulation of global epistasis is governed by effective genetic interactions

The paper shows that environmental factors, such as drug concentration, can significantly modulate global epistasis patterns in a four-mutation fitness landscape.

When Vibrios Take Flight: A Meta-analysis of Pathogenic Vibrios Species in Wild and Domestic Birds

This study meta-analyzes 76 studies on pathogenic Vibrio species in birds, finding V. cholerae as the most prevalent, with implications for public health and the One Health paradigm.

The mutation effect reaction norm (Mu-RN) highlights environmentally dependent mutation effects and genetic interactions

The paper introduces the mutation effect reaction norm (Mu-RN) to analyze mutation effects and genetic interactions across environments, using a compensatory ratchet mutation as a case study.

The Host Cell's Endoplasmic Reticulum Proteostasis Network Profoundly Shapes the Protein Sequence Space Accessible to HIV Envelope

This study shows that upregulating the host ER proteostasis network via the UPR reduces mutational tolerance of HIV Env, with some regions becoming more tolerant, suggesting host proteostasis influences HIV adaptation.

Deconstructing taxa x taxa x environment interactions in the microbiota: A theoretical examination

The paper uses a mathematical approach to examine how higher-order microbial taxa interactions affect host infection risk across different environmental contexts.

Reversion is most likely under high mutation supply, when compensatory mutations don't fully restore fitness costs

This study shows that high mutation rates increase reversion to wild type when compensation is partial, but fully compensatory mutations reduce reversion probability.

The epidemiological signature of pathogen populations that vary in the relationship between free-living survival and virulence

This study uses a mathematical model to show that small changes in parasite survival across different virulence-survival relationships significantly affect epidemiological outcomes like R0 and infectious peak size.

Experimental evolution for niche breadth in bacteriophage T4 highlights the importance of structural genes

This study uses experimental evolution of bacteriophage T4 in different host environments to show that structural genes are key determinants of niche breadth evolution.

Lexical landscapes as large in silico data forexamining advanced properties of fitness landscapes

This paper uses Google ngram data to create lexical landscapes as in silico fitness landscapes to explore evolutionary concepts like epistasis and clonal competition.