R. Horvath

OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution

This study investigates how OPA1 and its disease-causing mutants affect mitochondrial nucleoid distribution using high-resolution microscopy and a novel model.

The evolution of transposable elements in Brachypodium distachyon is governed by purifying selection, while neutral and adaptive processes play a minor role

This study investigates the evolutionary forces acting on transposable elements in Brachypodium distachyon, finding that purifying selection dominates over neutral and adaptive processes.

Small molecule inhibitors of transcriptional Cyclin Dependent Kinases impose HIV-1 latency, presenting "block and lock" treatment strategies

The paper shows that small molecule inhibitors of CDK7, CDK9, and CDK8/19 can induce HIV-1 latency, with CDK8/19 inhibitors maintaining latency after drug removal.

Polygenic architecture of flowering time and its relationship with local environments in the grass Brachypodium distachyon.

This study investigates the polygenic architecture of flowering time in Brachypodium distachyon, linking genetic variation to environmental factors and vernalization requirements.

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

This study shows CDK8/19 inhibitors reduce HIV-1 reactivation and enhance provirus latency in T cells by impairing RNA Pol II recruitment to the HIV-1 LTR.

The demographic history of the wild crop relative Brachypodium distachyon is shaped by distinct past and present ecological niches.

This study analyzes the demographic history of Brachypodium distachyon using genomic data to show how ecological niches shaped its population dynamics and genetic adaptation.

Genomic signatures of sexual selection on pollen-expressed genes in Arabis alpina

The paper analyzes genomic signatures of sexual selection on pollen-expressed genes in Arabis alpina, finding stronger purifying selection in outbred populations.

Microsecond resolved infrared spectroscopy on non-repetitive protein reactions by applying caged-compounds and quantum cascade laser frequency combs

This study uses dual comb quantum cascade laser spectroscopy to achieve microsecond time resolution for non-repetitive protein reactions, demonstrating its application to G-proteins and their complexes.

Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa

This study investigates the population genomic effects of polyploidy in Arabidopsis arenosa, finding subtle yet widespread impacts on evolutionary processes.