Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis
H. Imamura, S. Sakamoto, T. Yoshida, Y. Matsui, S. Penuela, D. Laird, S. Mizukami, K. Kikuchi, A. Kakizuka
The paper develops FRET biosensors to show that caspase-3 activation initiates a programmed loss of ATP in apoptotic cells via pannexin-1 cleavage, which arrests metabolic activity.
bioRxiv · Aug 14, 2020Cell Biology