S. Penuela

Pannexin 1 and Pannexin 3 differentially regulate the tumorigenic properties of cutaneous squamous cell carcinoma

This study investigates the differential roles of PANX1 and PANX3 in cutaneous squamous cell carcinoma, finding PANX1 promotes tumorigenesis while PANX3 suppresses it.

Global Pannexin 1-deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model.

This study shows that deleting Pannexin 1 in a melanoma mouse model increases CD8+ T cell infiltration without affecting tumor growth or survival.

Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model

This study shows that aged PANX3 knockout mice develop severe primary osteoarthritis, suggesting PANX3 deletion harms joint health in aging.

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

This study shows that deleting Panx3 in mice leads to increased knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

Pannexin 3 channels regulate architecture, adhesion, barrier function and inflammation in the skin

This study shows PANX3 is essential for maintaining skin architecture, adhesion, barrier function, and inflammation during aging, as demonstrated in knockout mice.

Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner

This study shows that PANX3 deletion reduces fat mass and inflammation in male mice but not females, with male KOs having fewer adipocytes and lower inflammatory gene expression.

Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

The paper develops FRET biosensors to show that caspase-3 activation initiates a programmed loss of ATP in apoptotic cells via pannexin-1 cleavage, which arrests metabolic activity.