K. Kikuchi

Trifunctional fatty acid derivatives demonstrate the impact of diazirine placement

The paper synthesizes three palmitic acid derivatives with diazirine at different positions and shows that end-position diazirines crosslink distinct protein subsets.

The Architecture of Sponge Choanocyte Chambers Maximizes Mechanical Pumping Efficiency

The paper investigates the mechanical pumping efficiency of sponge choanocyte chambers by combining imaging and computational models, finding that their spherical shape and outlet angle optimize flow.

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

The paper identifies a conserved mechanism, RePrESS, by which autoreactive innate-like T cells maintain tolerance through rewiring of the TCR signalosome.

Glucose stockpile in the intestinal apical brush border in C. elegans

The paper measures glucose diffusion in C. elegans intestinal brush border, finding it significantly slower than in bulk, suggesting a glucose stockpile in this viscous layer.

Activation of Nedd4L Ubiquitin Ligase by FCHO2-generated Membrane Curvature

This study shows that FCHO2-generated membrane curvature activates Nedd4L by relieving its autoinhibition, facilitating ENaC ubiquitination and endocytosis.

Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells

This study identifies Map7D2 and Map7D1 as regulators of microtubule stability in neuronal cells, showing they function through distinct mechanisms.

Cardioluminescence in transgenic zebrafish embryos: a calcium imaging tool to study drug effects and pathological modeling

This paper develops a cardioluminescence model in zebrafish embryos to monitor calcium dynamics, showing changes in Ca2+ levels with drug treatments and pathological conditions.

Heme oxygenase limits mycobacterial infection-induced ferroptosis

This study identifies zebrafish Hmox1a as a protective factor against mycobacterial infection by reducing iron accumulation and ferroptosis.

Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

This study uses single-cell RNA sequencing to identify nine hemocyte subpopulations in shrimp and their differentiation pathways.

Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid

This study shows that c9,t11 CLA reduces amyloid-beta production in neurons by altering BACE1 and APP localization, potentially protecting against neurodegeneration.

Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

The paper develops FRET biosensors to show that caspase-3 activation initiates a programmed loss of ATP in apoptotic cells via pannexin-1 cleavage, which arrests metabolic activity.

Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection of adult zebrafish

This study compares immune responses to smooth and rough variants of Mycobacterium abscessus in zebrafish, showing differential control by host immunity.