T. Yoshida

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.

Improved bladder cancer antitumor efficacy with a recombinant BCG that releases a STING agonist

This study evaluates a recombinant BCG strain that releases a STING agonist, showing improved antitumor efficacy in bladder cancer models compared to wild-type BCG.

Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents

This paper introduces a flexible carbon fiber electrode-thread array for recording dopamine activity in multiple deep brain targets in rodents and demonstrates its spatial resolution and integration with histological analysis.

Phylogenetic diversity of the carbon monoxide-utilizing prokaryotes and their divergent carbon monoxide metabolisms in the human gut microbiome

The paper identifies over a thousand CO-utilizing prokaryotes in the human gut microbiome, revealing diverse CO metabolism and a degenerated Wood-Ljungdahl pathway.

APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice

This paper uses two transgenic mouse models to study APOL1 risk variants' effects on glomerular disease, identifying shared and distinct transcriptional changes in podocytes.

Characteristics of the rumen virome in Japanese cattle

This study characterizes the rumen virome of Japanese cattle by constructing a viral genome catalog and identifying viral roles in feed digestion and methane production.

Identification of key virus--prokaryote infection pairs that contribute to viral shunt in a freshwater lake

The paper identifies key virus-prokaryote infection pairs that drive viral shunt in a freshwater lake by analyzing metagenomic data from surface and deep layers over a year.

HIV viral protein R induces loss of DCT1-type renal tubules

This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.

Taxonomic difference in marine bloom-forming phytoplanktonic species affects dynamics of both bloom-responding prokaryotes and prokaryotic viruses

This study shows that different phytoplankton species affect the dynamics of prokaryotes and their viruses during blooms.

Isolation and genomic and physiological characterization of Parageobacillus sp. G301, the isolate capable of both hydrogenogenic and aerobic carbon monoxide oxidation

This paper isolates and characterizes Parageobacillus sp. G301, a novel CO oxidizer capable of both hydrogenogenic and aerobic CO oxidation using both Ni-CODH and Mo-CODH.

Divergent ecological responses to typhoon disturbance revealed via landscape-scale acoustic monitoring

This study uses landscape-scale acoustic monitoring to reveal divergent ecological responses to typhoons, showing increased spatial variability in biological sound production and species detections.

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

Angiotensin II Type 2 Receptor Potentiates Skeletal Muscle Satellite Cell Differentiation via the GSK3β/β-catenin Pathway

This study shows that the AT2R/GSK3β/β-catenin pathway promotes skeletal muscle satellite cell differentiation and regenerative potential, offering a potential therapeutic target for diseases like CHF and CKD.

INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIA

This study shows that IGF-1 reduces coronary atherosclerosis and promotes stable plaque features in FH pigs, with spatial transcriptomics revealing potential mechanistic insights.

Differences in environmental stability among SARS-CoV-2 variants of concern: Omicron has higher stability

This study compares the environmental stability of SARS-CoV-2 variants, finding Omicron has the longest survival time on surfaces and is more resistant to ethanol than the Wuhan strain.

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

Prevalence of viral frequency-dependent infection in coastal marine prokaryotes revealed using monthly time series virome analysis

The paper analyzes monthly virome and 16S rRNA data from Osaka Bay to show frequency-dependent viral infection in marine prokaryotes, regardless of host growth strategy.

A Novel Power-Amplified Jumping Behavior in Larval Beetles (Coleoptera: Laemophloeidae)

This paper describes a novel jumping behavior in Laemophloeus biguttatus beetle larvae, suggesting the use of a latch-mediated spring actuation mechanism for efficient locomotion.

A user-friendly tool for cloud-based whole slide image segmentation, with examples from renal histopathology

Histo-Cloud is a cloud-based tool for whole slide image segmentation that simplifies access for non-experts, demonstrating its use in renal histopathology.

Isolation and characterization of novel temperate virus Aeropyrum globular virus 1 infecting hyperthermophilic archaeon Aeropyrum

This paper isolates and characterizes a novel archaeal virus AGV1, showing it lacks integration into the host genome and replicates only under stress conditions.

Year-round dynamics of amplicon sequence variant communities differ among eukaryotes, Mimiviridae, and prokaryotes in a coastal ecosystem

A one-year observation of coastal microbial communities revealed similar but different community dynamics for eukaryotes, a group of large viruses, and prokaryotes.

Massive occurrence of benthic plastic debris at the abyssal seafloor beneath the Kuroshio Extension, the North West Pacific

The paper quantifies plastic debris on the abyssal seafloor beneath the Kuroshio Extension, finding high densities of single-use plastics, indicating the Northwest Pacific deep-sea basin is a major plastic reservoir.

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

The paper develops FRET biosensors to show that caspase-3 activation initiates a programmed loss of ATP in apoptotic cells via pannexin-1 cleavage, which arrests metabolic activity.

Multi-organ signaling mobilizes tumor-associated erythroid cells expressing immune checkpoint molecules

This study shows that tumor-induced stress increases erythroid cell production in mice, which express immune checkpoint molecules and contribute to tumor growth.

Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

This study sequenced the genome of a kleptoplastic sea slug and found no evidence of algal gene transfer to the nucleus, showing photosynthesis can occur without nuclear gene transfer.

Why species richness of plants and herbivorous insects do or do not correlate

The paper investigates how insect generality affects the correlation between plant and herbivorous insect species richness in semi-natural grasslands, finding that generality negatively impacts the correlation under specific conditions.

Genome-resolved viral and cellular metagenomes revealed potential key virus-host interactions in a deep freshwater lake

This study analyzes metagenomic data from a freshwater lake to identify viral-host interactions and diversity patterns in viral and bacterial communities.

Translocational unfolding in clostridial binary iota toxin complex

This study reports the structure of the clostridial binary toxin translocation channel and its complex with ADP-ribosyltransferase, revealing a novel mechanism of N-terminal unfolding for protein translocation.

Differential scanning fluorimetric analysis of the amino-acid binding to taste receptor using a model receptor protein, the ligand-binding domain of fish T1r2a/T1r3

This study uses differential scanning fluorimetry to analyze amino-acid binding to the T1r2a/T1r3LBD model receptor, showing thermal stabilization and specificity for L-amino acids.