S. M. Simon

RetroCHMP3 Blocks Budding of Enveloped Viruses Without Blocking Cytokinesis

The paper identifies duplicated and truncated CHMP3 variants in New World monkeys and mice that inhibit enveloped virus budding without affecting essential cellular ESCRT functions.

Cargo modulates the conformation of the nuclear pore in living cells

The paper shows that specific NPC components change conformation when interacting with cargo in living cells.

Cell-cell signaling elicits local Ca2+ transients in melanocyte dendrites and dendritic spine-like structures

The paper shows that human melanocytes exhibit local Ca2+ transients in dendrites and spines when co-cultured with keratinocytes, driven by secreted factors.

Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly

The paper observes ESCRT-III recruitment and timing during HIV-1 membrane scission, showing they arrive after membrane bending and depart before scission.

DNAJB1-PRKACA fusion kinase interacts with β-catenin and liver regenerative response to drive fibrolamellar hepatocellular carcinoma

This study shows that the DNAJB1-PRKACA fusion kinase drives fibrolamellar hepatocellular carcinoma in mice and identifies β-catenin activation and environmental factors as contributors to tumor progression.