ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth
W. K. Ma, D. M. Voss, J. Scharner, A. S. H. Costa, K.-T. Lin, H. Y. Jeon, J. E. Wilkinson, M. Jackson, F. Rigo, F. C. Bennett, A. Krainer
This paper demonstrates that ASO-based PKM splice-switching therapy inhibits HCC cell growth by converting PKM2 to PKM1, altering glucose metabolism and reducing tumorigenesis.
bioRxiv · Sep 1, 2020Cancer Biology