Author

K.-T. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. R. Krainer· 2 shared Y.-C. Chen· 2 shared A. Geier· 1 shared A. K. Kesarwani· 1 shared A. Krainer· 1 shared A. S. H. Costa· 1 shared C. Hu· 1 shared C.-C. Chien· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

A. R. Krainer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Whole-Cell Screening Platform to Discover Cell Adhesion Molecules that Enable Programmable Bacterial Cell-Cell Adhesion

P.-Y. Chen, Y.-C. Chen, P.-P. Chen, K.-T. Lin, W.-L. Wang, K.-C. Hsia, S.-Y. Ting

This paper introduces a whole-cell screening platform to identify cell adhesion molecules targeting bacterial membrane proteins, successfully discovering functional CAMs that recognize three outer membrane proteins.

bioRxiv · Dec 3, 2023Microbiology

Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2

R.-H. Wang, P.-R. Chen, Y.-T. Chen, Y.-C. Chen, Y.-H. Chu, C.-C. Chien, P.-C. Chien, S.-Y. Lo, Z.-L. Wang, M.-C. Tsou, S.-Y. Chen, G.-S. Chiu, W.-L. Chen, Y.-H. Wu, L. Wang, , K.-T. Lin

This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.

bioRxiv · Sep 2, 2023Cancer Biology

Loss of KRASG12D feedback regulation involving splicing factor SRSF1 accelerates pancreatic cancer

L. Wan, K.-T. Lin, M. A. Rahman, Z. Wang, M. A. Jensen, Y. Park, D. A. Tuveson, A. R. Krainer

The paper shows that loss of SRSF1, a splicing factor, accelerates pancreatic cancer by disrupting homeostasis and enhancing KrasG12D-driven tumorigenesis.

bioRxiv · Oct 13, 2021 · PreprintCancer Biology

ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth

W. K. Ma, D. M. Voss, J. Scharner, A. S. H. Costa, K.-T. Lin, H. Y. Jeon, J. E. Wilkinson, M. Jackson, F. Rigo, F. C. Bennett, A. Krainer

This paper demonstrates that ASO-based PKM splice-switching therapy inhibits HCC cell growth by converting PKM2 to PKM1, altering glucose metabolism and reducing tumorigenesis.

bioRxiv · Sep 1, 2020Cancer Biology

Differential functions of splicing factors in breast-cancer initiation and metastasis

S. Das, M. Akerman, S. Park, M. Brugioli, A. Geier, A. K. Kesarwani, M. Fan, N. Leclair, L. Urbanski, K.-T. Lin, C. Hu, X. Hua, J. George, S. K. Muthuswamy, A. R. Krainer, O. Anczukow

This study identifies splicing factors involved in breast cancer initiation and metastasis, showing their differential roles and interactions with MYC.

bioRxiv · May 10, 2019Cancer Biology