Cancer BiologybioRxiv
ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth
W. K. Ma, D. M. Voss, J. Scharner…·A. Krainer
This paper demonstrates that ASO-based PKM splice-switching therapy inhibits HCC cell growth by converting PKM2 to PKM1, altering glucose metabolism and reducing tumorigenesis.
DOI 10.1158/0008-5472.can-20-0948