Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt
B. L. Dunkerly-Eyring, M. Pinilla-Vera, D. McKoy, S. Mishra, M. I. Grajeda Martinez, C. U. Oeing, M. J. Ranek, D. A. Kass
The paper shows that a single serine on TSC2 selectively controls mTORC1 activation by ERK1/2 but not Akt, with implications for pathological versus physiological mTOR signaling.
bioRxiv · Jul 13, 2021 · PreprintCell Biology