HLA binding of self-peptides is biased towards proteins with specific molecular functions
Vadim K Karnaukhov, Wayne Paes, Isaac B. Woodhouse, Thomas Partridge, Annalisa Nicastri, Simon Brackenridge, D. N. Scherbinin, Dmitriy M. Chudakov, Ivan V. Zvyagin, Nicola Ternette, Hashem Koohy, Persephone Borrow, Mikhail Shugay
The paper shows HLA alleles preferentially present peptides from proteins with specific molecular functions, linking these preferences to HLA allele differences and disease susceptibility.
bioRxiv · Feb 16, 2021 · PreprintBioinformatics