Annalisa Nicastri

This study shows that Coxsackievirus B3 evades CD8+ T-cell immunity by downregulating HLA Class I and viral peptide presentation, while inducing robust CD4+ T-cell responses and memory formation.

The paper integrates immunopeptidomics and immunoinformatics to characterize BoLA-DR antigen presentation and identify CD4 T cell epitopes with high predictive accuracy.

The paper shows HLA alleles preferentially present peptides from proteins with specific molecular functions, linking these preferences to HLA allele differences and disease susceptibility.