Author

D. N. Woolfson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1

Frequent Co-Authors

G. G. Rhys· 3 shared A. R. Thomson· 2 shared J. A. Cross· 2 shared J. F. Weijman· 2 shared J. L. Beesley· 2 shared J. Mantell· 2 shared M. P. Dodding· 2 shared R. L. Brady· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

G. G. Rhys

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Author profile →

5 papers

Recent·Most cited

Molecular architecture of the autoinhibited kinesin-1 lambda particle

J. F. Weijman, S. Y. Kadapalakere, K. J. Surridge, J. A. Cross, U. Borucu, J. Mantell, D. N. Woolfson, C. Schaffitzel, M. P. Dodding

The paper integrates computational structure prediction with electron microscopy to reveal the coiled-coil architecture of the autoinhibited compact form of kinesin-1.

bioRxiv · Apr 28, 2022Cell Biology

How coiled-coil assemblies accommodate multiple aromatic residues

G. G. Rhys, W. M. Dawson, J. L. Beesley, F. J. O. Martin, L. Brady, A. R. Thomson, D. N. Woolfson

This study investigates how tyrosine-rich sequences form coiled-coil assemblies and resolves new structures showing different packing arrangements of aromatic residues.

bioRxiv · Feb 1, 2021Biochemistry

Coiled coils 9-to-5: Rational de novo design of α-helical barrels with tunable oligomeric states

W. M. Dawson, F. J. Martin, G. G. Rhys, K. L. Shelley, R. L. Brady, D. N. Woolfson

This study designs α-helical barrels with tunable oligomeric states by modifying residue size in coiled-coil sequences, supported by X-ray crystal structures.

bioRxiv · Jan 20, 2021Biochemistry

Molecular mechanism for kinesin-1 direct membrane recognition

Z. Anton, J. F. Weijman, C. Williams, E. R. R. Moody, J. Mantell, Y. Y. Yip, J. A. Cross, T. A. Williams, R. A. Steiner, M. Crump, D. N. Woolfson, M. P. Dodding

This paper identifies a conserved amphipathic helix in kinesin-1 light chains that mediates direct membrane binding, challenging the previous understanding of lysosome positioning.

bioRxiv · Jan 20, 2021Cell Biology

Navigating the structural landscape of de novo α-helical bundles

G. G. Rhys, C. W. Wood, J. L. Beesley, N. R. Zaccai, A. J. Burton, R. L. Brady, A. R. Thomson, D. N. Woolfson

This paper designs a hyperstable antiparallel coiled-coil tetramer by analyzing structural transitions in synthetic peptides.

bioRxiv · Dec 21, 2018Biochemistry