Author

R. A. Steiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

M. P. Dodding· 2 shared S. Bui· 2 shared A. Liuzzi· 1 shared A. M. Orville· 1 shared A. Politis· 1 shared A. Royant· 1 shared C. Cordery· 1 shared C. Rivetti· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

M. P. Dodding

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cysteine enrichment mediates co-option of uricase in reptilian skin and transition to uricotelism

G. Mori, A. Liuzzi, L. Ronda, M. Di Palma, M. S. Chegkazi, S. Bui, M. Garcia-Maya, J. Ragazzini, M. Malatesta, E. Della Monica, C. Rivetti, P. Antin, S. Bettati, R. A. Steiner, R. Percudani

This study identifies a cysteine-rich urate oxidase in chickens that retains urate oxidation but can also regenerate urate, suggesting a repurposed role in reptilian skin and uricotelism.

bioRxiv · Jun 2, 2023 · PreprintEvolutionary Biology

A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron binding protein FutA from Prochlorococcus

R. Bolton, M. M. Machelett, J. Stubbs, D. Axford, N. Caramello, L. Catapano, M. Maly, M. J. Rodrigues, C. Cordery, G. J. Tizzard, F. MacMillan, S. Engilberge, D. von Stetten, T. Tosha, H. Sugimoto, , I. Tews

This paper reveals a redox switch in the cyanobacterial iron binding protein FutA that allows it to bind both Fe(II) and Fe(III) ions through structural analysis.

bioRxiv · May 23, 2023 · PreprintBiophysics

Evolutionary adaptation from hydrolytic to oxygenolytic catalysis

S. Bui, S. Gil-Guerrero, P. van der Linden, P. Carpentier, M. Ceccarelli, P. G. Jambrina, R. A. Steiner

This paper investigates how the ABH-fold protein evolved to catalyze oxygenation reactions by repurposing its original hydrolytic function through structural and computational analysis.

bioRxiv · May 5, 2023 · PreprintBiochemistry

Molecular mechanism for kinesin-1 direct membrane recognition

Z. Anton, J. F. Weijman, C. Williams, E. R. R. Moody, J. Mantell, Y. Y. Yip, J. A. Cross, T. A. Williams, R. A. Steiner, M. Crump, D. N. Woolfson, M. P. Dodding

This paper identifies a conserved amphipathic helix in kinesin-1 light chains that mediates direct membrane binding, challenging the previous understanding of lysosome positioning.

bioRxiv · Jan 20, 2021Cell Biology

Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

S. Pernigo, M. Chegkazi, Y. Yip, C. Treacy, G. Glorani, K. Hansen, A. Politis, M. P. Dodding, R. A. Steiner

This study identifies Y-acidic motifs recognized by KLC1TPR in kinesin-1, distinct from W-acidic motifs, and proposes a model for their differential activity promotion.

bioRxiv · May 14, 2018Biochemistry