Retroelement-Age Clocks: Epigenetic Age Captured by Human Endogenous Retrovirus and LINE-1 DNA methylation states
L. Ndhlovu, M. Bendall, V. B. Dwaraka, A. P. Pang, N. Dopkins, N. Carreras, R. Smith, D. Nixon, M. J. Corley
This study constructs epigenetic clocks using retroelement DNA methylation states to predict chronological age across human tissues and species, showing their reversibility and responsiveness to HIV treatment.
bioRxiv · Dec 6, 2023 · PreprintImmunology