Author

J. Van Weyenbergh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 1 Cancer Biology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 6 Research Focus:differential expression· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3

Frequent Co-Authors

T. Dierckx· 4 shared A. Bafica· 2 shared D. S. Mansur· 2 shared R. Khouri· 2 shared A. A. Santos· 1 shared A. Beauvois· 1 shared A. Bittencourt· 1 shared A. J. Meneses Filho· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersImmunology

T. Dierckx

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Tittle: An integrated analysis of the structural changes and gene expression of spleen in human visceral leishmaniasis with and without HIV coinfection

J. L. M. Fontes, R. Khouri, L. G. C. Reinaldo, E. M. A. Hassegawa, A. J. Meneses Filho, C. V. B. de Melo, P. I. P. Ramos, R. de Deus Moura, C. Pagliari, M. Santos, R. J. C. Araujo, J. Van Weyenbergh, L. A. R. de Freitas, C. H. N. Costa, W. L. C. dos-Santos

This study compares structural and gene expression changes in spleens of visceral leishmaniasis patients with and without HIV coinfection, identifying key pathways and gene associations linked to spleen disorganization.

bioRxiv · Dec 21, 2023Pathology

TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

J. Verhoeven, K. A. Jacobs, F. Rizzollo, F. Lodi, Y. Hua, J. Pozniak, A. N. Srinvasan, D. Houbaert, G. Shankar, S. More, M. B. Schaaf, N. Dubroja Lakic, M. Ganne, J. Lamote, J. Van Weyenbergh, , P. Agostinis

This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.

bioRxiv · Apr 21, 2023Cancer Biology

Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule

S. Maseko, I. Van Molle, K. Blibek, C. Gorgulla, J. Olivet, J. Blavier, C. Vandermeulen, S. Skupiewski, D. Saha, T. Ntombela, J. Lim, F. Lembo, A. Beauvois, M. Hamaidia, J.-P. Borg, , J.-C. Twizere

This study identifies the structural basis of Tax-1 interaction with syntenin-1 and demonstrates small-molecule inhibition of this interaction to target HTLV-1.

bioRxiv · Aug 25, 2021 · PreprintBiochemistry

Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19

R. O. Formiga, F. C. Amaral, C. F. Souza, D. A. G. B. Mendes, C. W. S. Wanderley, C. B. Lorenzini, A. A. Santos, J. Antonia, L. F. Faria, C. C. Natale, N. M. Paula, P. C. S. Silva, F. R. Fonseca, L. Aires, N. Heck, , F. Spiller

This paper shows neuraminidase inhibitors reduce neutrophil overactivation in sepsis and COVID-19 by inhibiting sialic acid release and ROS production.

bioRxiv · Nov 12, 2020 · PreprintImmunology

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

R. Boudewijns, H. J. Thibaut, S. J. F. Kaptein, R. Li, V. Vergote, L. Seldeslachts, C. De Keyzer, L. Bervoets, S. Sharma, J. Van Weyenbergh, L. Liesenborghs, J. Ma, S. Jansen, D. Van Looveren, T. Vercruysse, , X. Saelens

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology

Serum GlycA level is a candidate biomarker for disease activity in systemic lupus erythematosus and for proliferative status of lupus nephritis, independent of renal function impairment.

T. Dierckx, S. Goletti, L. Chiche, L. Daniel, B. Lauwerys, N. Jourde-Chiche, J. Van Weyenbergh

This study shows Serum GlycA is elevated in systemic lupus erythematosus and correlates with disease activity and lupus nephritis, outperforming traditional biomarkers in predicting proliferative LN.

bioRxiv · Dec 12, 2018 · PreprintImmunology

Age but not disease progression defines CD4+ and CD8+ T stem cell memory levels in human retroviral infections: contrasting effects of HTLV-1 and HIV-1

S. M. Menezes, F. E. Leal, S. Pereira Ribeiro, T. Dierckx, M. Roederer, D. SenGupta, D. Nixon, J. Van Weyenbergh

This study compares CD4+ and CD8+ TSCM levels in HTLV-1 and HIV-1 infections, finding age-driven accumulation in HTLV-1 and age-related loss in HIV-1 after treatment.

bioRxiv · Nov 19, 2018 · PreprintImmunology

Decreased RORC expression and downstream signaling in HTLV-1-associated Adult T-cell Lymphoma/Leukemia uncovers an antiproliferative IL17 link: a potential target for immunotherapy?

K. Subramanian, T. Dierckx, R. Khouri, S. M. Menzes, L. Farre, A. Bittencourt, K. Kataoka, S. Ogawa, J. Van Weyenbergh

The paper identifies decreased RORC expression and downstream antiproliferative IL17 signaling in ATL, suggesting therapeutic potential for boosting RORC/IL17 signaling.

bioRxiv · May 21, 2018Immunology

ISG15 induces IL-10 production in human monocytes and is a biomarker of disease severity during active tuberculosis

P. F. dos Santos, J. Van Weyenbergh, M. Delgobo, D. d. O. Patricio, B. J. Ferguson, R. GUABIRABA, T. Dierckx, S. M. M. MENEZES, A. Bafica, D. S. Mansur

The paper shows ISG15 induces IL-10 in human monocytes and correlates with TB disease severity.

bioRxiv · Aug 2, 2017Immunology