Heme stimulates platelet mitochondrial oxidant production via the activation of toll-like receptor 4 signaling to mediate targeted granule secretion
G. K. Annarapu, D. Nolfi-Donegan, M. Reynolds, Y. Wang, L. Kohut, B. Zuckerbraun, S. Shiva
This study shows that heme activates platelet TLR4 signaling, leading to mitochondrial ROS production and targeted granule secretion, with implications for thrombo-inflammatory responses.
bioRxiv · Aug 2, 2021Cell Biology