S. Shiva

Myoglobin Inhibits Breast Cancer Cell Fatty Acid Oxidation and Migration via Heme-Dependent Oxidant Production and Not Fatty Acid Binding

Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy

This study compares the therapeutic efficacy of mitochondria-containing extracellular vesicles from mouse and human brain endothelial cells in a mouse stroke model, finding that mouse-derived vesicles are more effective.

Lysosomal mitochondrial interaction promotes tumor growth in squamous cell carcinoma of the head and neck

This study shows that lysosomal-mitochondrial interaction (LMI) promotes tumor growth in squamous cell carcinoma of the head and neck by enhancing mitochondrial complex I activity and lysosomal function.

Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

This study shows that reduced GCN5L1 expression in the failing heart leads to mitochondrial dysfunction and decreased bioenergetic output.

Myoglobin promotes cardiomyocyte differentiation through oxidatively modulating the Hippo Kinase Pathway

This study shows myoglobin promotes cardiomyocyte differentiation by modulating the Hippo pathway through oxidative regulation of LATS1 and YAP.

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

This study shows that frataxin deficiency in endothelial cells causes mitochondrial respiration defects and vasoconstriction, contributing to pulmonary hypertension.

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

Mitochondria-containing EVs Protect Brain Endothelial Cells and Reduce Mouse Brain Infarct Sizes

This paper shows that medium-to-large extracellular vesicles (m/lEVs) protect brain endothelial cells by transferring mitochondria and reducing brain infarct sizes in a mouse stroke model.

Heme stimulates platelet mitochondrial oxidant production via the activation of toll-like receptor 4 signaling to mediate targeted granule secretion

This study shows that heme activates platelet TLR4 signaling, leading to mitochondrial ROS production and targeted granule secretion, with implications for thrombo-inflammatory responses.

iPSC modeling shows uncompensated mitochondrial mediated oxidative stress underlies early heart failure in hypoplastic left heart syndrome

This study uses iPSC-derived cardiomyocytes to show that mitochondrial oxidative stress and ER stress underlie early heart failure in HLHS patients.

Microvesicles Transfer Mitochondria and Increase Mitochondrial Function in Brain Endothelial Cells

This paper shows that microvesicles transfer mitochondria to brain endothelial cells and neurons, increasing ATP levels under ischemic conditions, while exosomes do not affect mitochondrial function.

High Mobility Group Box 1 enhances ADP-mediated platelet activation by increasing platelet surface P2Y12 localization

This study shows HMGB1 enhances ADP-mediated platelet activation by increasing P2Y12 receptor localization, but not by thrombin or collagen.

DIFFERENTIAL BIOENERGETICS IN ADULT RAT CARDIOMYOCYTES ISOLATED FROM THE RIGHT VERSUS LEFT VENTRICLE

The paper compares bioenergetics in adult rat cardiomyocytes from the right and left ventricle, finding greater maximal respiration and glycolytic rate in right ventricle cells.