Author

D. O'Connell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

A. D. T. Barrett· 1 shared A. Hirst· 1 shared A. J. M. Wollman· 1 shared A. P. C. Lim· 1 shared A. Schlessinger· 1 shared A. Velduis-Vlug· 1 shared B. J. Hanson· 1 shared B. Misof· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMicrobiology

A. D. T. Barrett

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

C.-C. Tang, C. Castro, M. J. O'Meara, S.-H. Yoon, D. J. Brooks, M. L. Bouxsein, J. d. S. Martins, J. Wang, N. S. Gray, B. Misof, P. Roschger, S. Boulin, K. Klaushofer, A. Velduis-Vlug, Y. Vegting, , M. N. Wein

The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.

bioRxiv · Feb 26, 2021Physiology

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody

C. E. Z. Chan, S. G. K. Seah, D. H. Chye, S. Massey, M. Torres, A. P. C. Lim, S. K. K. Wong, J. J. Y. Neo, P. S. Wong, J. H. Lim, G. S. L. Loh, D. L. Wang, J. D. Boyd-Kirkup, S. Guan, D. Thakkar, , B. J. Hanson

The paper identifies SC31, a potent SARS-CoV-2 neutralizing antibody, and shows that its Fc-mediated effector functions are critical for its therapeutic efficacy in vivo.

bioRxiv · Oct 26, 2020Microbiology

Biophysical characterization of DNA origami nanostructures reveals inaccessibility to intercalation binding sites

H. Miller, S. A. Contera, A. J. M. Wollman, A. Hirst, K. Dunn, S. Schroeter, D. O'Connell, M. C. Leake

The paper investigates intercalation binding site accessibility in DNA origami nanostructures using biophysical methods and finds that not all sites are accessible for dye intercalation.

bioRxiv · Nov 16, 2019Biophysics