Author

D. P. Giedroc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 7 Approach:experimental assay· 6 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

K. A. Edmonds· 4 shared D. A. Capdevila· 3 shared G. Gonzalez-Gutierrez· 3 shared Y. Zhang· 3 shared H. Wu· 2 shared M. E. Winkler· 2 shared A. B. Dalia· 1 shared A. Garrett· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiochemistry

K. A. Edmonds

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance.

N. R. De Lay, N. Verma, D. Sinha, A. Garrett, M. K. Osterberg, S. Reiling, D. Porter, D. P. Giedroc, M. E. Winkler

This paper identifies five CiaR-controlled Ccn sRNAs in S. pneumoniae that modulate Zn resistance and virulence by regulating metal homeostasis and detoxification mechanisms.

bioRxiv · Nov 7, 2023 · PreprintMicrobiology

Increased intracellular persulfide levels attenuate HlyU-mediated hemolysin transcriptional activation in Vibrio cholerae

C. M. P. Diez, G. T. Antelo, T. N. Dalia, A. B. Dalia, D. P. Giedroc, D. A. Capdevila

This study shows that intracellular persulfide levels reduce HlyU-mediated hemolysin gene activation in V. cholerae by modulating reactive sulfur species sensing.

bioRxiv · Mar 13, 2023 · PreprintBiochemistry

Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine

Y. Zhang, G. Gonzalez-Gutierrez, K. A. Legg, K. A. Edmonds, D. P. Giedroc

The paper identifies and characterizes an ABC transporter in Streptococcus pneumoniae that specifically transports ergothioneine, revealing its structure and conservation across bacterial species.

bioRxiv · May 2, 2022 · PreprintBiochemistry

Functional asymmetry and chemical reactivity of CsoR family persulfide sensors

J. Fakhoury, Y. Zhang, K. A. Edmonds, M. Bringas, J. Luebke, G. Gonzalez-Gutierrez, D. A. Capdevila, D. P. Giedroc

This study investigates the molecular basis of reactive sulfur species specificity in CstR proteins, revealing structural and chemical asymmetry in their reactivity.

Nucleic Acids Research · Nov 10, 2021Peer-reviewedBiochemistry

Structural determinants of persulfide-sensing specificity in a dithiol-based transcriptional regulator

D. A. Capdevila, B. J. C. Walsh, Y. Zhang, C. M. Dietrich, G. Gonzalez-Gutierrez, D. P. Giedroc

The paper identifies structural determinants of persulfide-sensing specificity in SqrR, showing that structural frustration of the disulfide form enhances tetrasulfide bridge formation and persulfide selectivity.

bioRxiv · Mar 22, 2020Biochemistry

Structure of the large extracellular loop of FtsX and its interaction with the essential peptidoglycan hydrolase PcsB in Streptococcus pneumoniae

B. E. Rued, M. Alcorlo, K. A. Edmonds, S. Martinez-Caballero, D. Straume, Y. Fu, K. E. Bruce, H. Wu, L. S. Havarstein, J. A. Hermoso, M. E. Winkler, D. P. Giedroc

This study presents the structure of FtsX's extracellular loop and shows its essential interaction with PcsB for cell viability in Streptococcus pneumoniae.

bioRxiv · Oct 2, 2018Microbiology

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

D. Capdevila, F. Huerta, K. A. Edmonds, M. T. Le, H. Wu, D. P. Giedroc

The paper identifies residues critical for allosteric activation in a bacterial repressor by analyzing ZnII-induced changes in atomic motions.

bioRxiv · Apr 16, 2018Biochemistry