Mice Lacking FXR Are Susceptible to Liver Ischemia-Reperfusion Injury
Y. Li, R. Xu, P. K. Rao, C. K. Gomes, E. R. Moran, M. Puchowicz, E. B. Chang, D. P. Yin, J. F. Pierre
This study shows that FXR deficiency increases liver damage and inflammation during ischemia-reperfusion injury, with altered bile acid metabolism and gut microbiota composition.
bioRxiv · Aug 19, 2019 · PreprintPhysiology