J. F. Pierre

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

This study shows that bariatric surgery followed by immune checkpoint blockade improves breast cancer outcomes in formerly obese mice, despite weight loss being less effective than diet in reducing tumor burden.

Dietary Lipid Oxidization Products Alter Growth, Adiposity and Gut Microbial Ecology in Prepubertal Porcine Model

This study examines the effects of dietary lipid oxidation products on growth, adiposity, and gut microbiome in prepubertal pigs, finding reduced growth and altered microbial communities.

The gut mycobiome of healthy mice is shaped by the environment and shapes metabolic outcomes in response to diet

This study investigates how gut fungal communities in mice influence metabolic outcomes in response to diet, finding that fungal composition correlates with body mass and metabolic biomarkers.

High fat diet disrupts diurnal interactions between REG3g and small intestinal gut microbes resulting in metabolic dysfunction

Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in liver and adipose tissue

This study shows that high sucrose intake causes different metabolic changes in male and female mice, affecting liver and fat tissue, and highlights the role of sex in lipid storage and liver disease development.

Mice Lacking FXR Are Susceptible to Liver Ischemia-Reperfusion Injury

This study shows that FXR deficiency increases liver damage and inflammation during ischemia-reperfusion injury, with altered bile acid metabolism and gut microbiota composition.

Fungi form interkingdom microbial communities in the primordial human gut that develop with gestational age

The paper examines fungal colonization in the primordial gut of newborns, finding that fungal communities become more complex with gestational age and may be linked to preterm birth.