Targeting primary and metastatic uveal melanoma with a G protein inhibitor
M. D. Onken, C. M. Makepeace, K. M. Kaltenbronn, J. Choi, L. Hernandez-Aya, K. N. Weilbaecher, K. D. Piggott, P. K. Rao, C. M. Yuede, A. J. Dixon, P. Osei-Owusu, J. A. Cooper, K. J. Blumer
This study evaluates the therapeutic potential of FR, a Gq/11 inhibitor, in uveal melanoma by testing its effects on tumor growth, apoptosis, and metastasis in cell lines and xenograft models.
bioRxiv · Jan 16, 2021 · PreprintCancer Biology