Author

D. Panagopoulos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Vedadi· 2 shared A. Aman· 1 shared A. Dong· 1 shared A. Kaghad· 1 shared A. Li· 1 shared A. Mamai· 1 shared C. A. Zepeda-Velazquez· 1 shared C. Arrowsmith· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

M. Vedadi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

S. Perveen, C. A. Zepeda-Velazquez, D. McLeod, R. Marcellus, M. Mohammed, M. Abbey, D. Ensan, D. Panagopoulos, V. Trush, E. Gibson, A. Dong, L. Halabelian, G. Poda, J. Owen, A. Aman, , M. Vedadi

This study identifies small molecule antagonists of RBBP4's top pocket, competes with protein and histone interactions, and reports the first crystal structure of RBBP4 with a small molecule.

bioRxiv · Jan 5, 2022 · PreprintBiochemistry

Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics

M. Sutherland, A. Li, A. Kaghad, D. Panagopoulos, F. Li, M. Szewczyk, D. Smil, C. Scholten, L. Bouche, T. Stellfeld, C. Arrowsmith, D. Barsyte, M. Vedadi, I. V. Hartung, H. Steuber, , V. Santhakumar

This study designs and synthesizes a new class of selective PRMT4 inhibitors with improved selectivity over other PRMT family members.

bioRxiv · Nov 17, 2020Pharmacology & Toxicology