Author

C. A. Zepeda-Velazquez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Schapira· 3 shared R. Al-awar· 3 shared A. Aman· 2 shared A. Dong· 2 shared C. H. Arrowsmith· 2 shared D. McLeod· 2 shared L. Halabelian· 2 shared M. Vedadi· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

M. Schapira

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 5, 2022

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

S. Perveen, C. A. Zepeda-Velazquez, D. McLeod…·M. Vedadi

This study identifies small molecule antagonists of RBBP4's top pocket, competes with protein and histone interactions, and reports the first crystal structure of RBBP4 with a small molecule.

DOI 10.1101/2022.01.05.475077

humanprotein structure

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 17, 2021

Structure Activity Relationship of USP5 Allosteric Inhibitors

M. K. Mann, C. A. Zepeda-Velazquez, H. G. Alvarez…·M. Schapira

This paper develops a chemical series of USP5 allosteric inhibitors, identifies a selective compound with structural and functional characterization.

DOI 10.1101/2021.05.17.444542

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivPreprintDec 4, 2020

A First-in-class, Highly Selective and Cell-active AllostericInhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

Y. Shen, F. Li, M. Szewczyk…·J. Jin

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

DOI 10.1101/2020.12.04.412569

experimental assaydrug response / drug discovery

𝕏 PostBluesky