Author

D. Pathak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

K. M. Ruppel· 2 shared A. Fernandez Trasancos· 1 shared A. Ferrarini· 1 shared A. Grinzato· 1 shared A. Hidalgo· 1 shared A. Houdusse· 1 shared C. Kikuti· 1 shared D. Auguin· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

K. M. Ruppel

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2 papers

Recent·Most cited

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

L. Sen Martin, A. Fernandez Trasancos, M. A. Lopez Unzu, D. Pathak, A. Ferrarini, V. Labrador Cantarero, D. Sanchez Ortiz, M. R. Pricolo, N. Vicente, D. Velazquez Carreras, L. Sanchez Garcia, J. A. Nicolas Avila, M. Sanchez Diaz, S. Schlossarek, L. Cusso, , J. Alegre Cebollada

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

bioRxiv · Mar 22, 2024Physiology

Cryo-EM structure of the folded-back state of human β-cardiac myosin

A. Grinzato, D. Auguin, C. Kikuti, N. Nandwani, D. Moussaoui, D. Pathak, E. Kandiah, K. M. Ruppel, J. A. Spudich, A. Houdusse, J. Robert-Paganin

The paper reports the 3.6 Å cryo-EM structure of the folded-back IHM state of human β-cardiac myosin, revealing HCM mutation hotspots and structural differences from smooth muscle myosin IHMs.

bioRxiv · Apr 15, 2023 · PreprintBiophysics