Author

S. Schlossarek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

L. Carrier· 3 shared G. Mearini· 2 shared I. Braren· 2 shared N. Pietsch· 2 shared A. Fernandez Trasancos· 1 shared A. Ferrarini· 1 shared A. Hidalgo· 1 shared A. Madsen· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPhysiology

L. Carrier

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

L. Sen Martin, A. Fernandez Trasancos, M. A. Lopez Unzu, D. Pathak, A. Ferrarini, V. Labrador Cantarero, D. Sanchez Ortiz, M. R. Pricolo, N. Vicente, D. Velazquez Carreras, L. Sanchez Garcia, J. A. Nicolas Avila, M. Sanchez Diaz, S. Schlossarek, L. Cusso, , J. Alegre Cebollada

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

bioRxiv · Mar 22, 2024Physiology

Chronic activation of tubulin tyrosination in HCM mice and human iPSC-engineered heart tissues improves heart function

N. Pietsch, C. Y. Chen, S. Kupsch, L. Bacmeister, B. Geertz, M. Herera-Rivero, H. Voss, E. Krämer, I. Braren, D. Westermann, H. Schlüter, G. Mearini, S. Schlossarek, J. van der Velden, M. A. Caporizzo, , L. Carrier

bioRxiv · May 25, 2023Physiology

ACTN2 mutant causes proteopathy in human iPSC-derived cardiomyocytes

A. T. Zech, M. Prondzynski, S. R. Singh, N. Pietsch, E. Orthey, E. Alizoti, J. Busch, A. Madsen, C. S. Behrens, M. Meyer-Jens, G. Mearini, M. D. Lemoine, E. Kraemer, D. Mosqueira, S. Virdi, , L. Carrier

This study shows that an ACTN2 mutation leads to proteopathy in human iPSC-derived cardiomyocytes through protein aggregation and activation of proteolytic systems.

bioRxiv · Oct 28, 2021Cell Biology