Development of a novel Francisella tularensis Live Vaccine Strain expressing ovalbumin provides insight into Francisella tularensis-specific CD8+ T cell responses.
D. E. Place, D. R. Williamson, Y. Yuzefpolskiy, B. Katkere, S. Sarkar, V. Kalia, G. S. Kirimanjeswara
This paper develops a novel F. tularensis vaccine strain expressing ovalbumin to study CD8+ T cell responses, finding that these cells expand early, produce IFN-γ, and have distinct kinetics in different tissues.
bioRxiv · Oct 10, 2017Immunology