T. Patel

Advancing CAR T-Cell Therapy: Simultaneously Attack Tumor and Immunosuppressive Cells in the Tumor Microenvironment

This paper develops a PD-L1-targeting CAR T-cell therapy (MC9999) that effectively attacks both tumor and immunosuppressive cells in solid tumors.

Rising daptomycin resistance in Enterococcus faecium across a hospital system occurred via rampant recurrent evolution and occasional transmission between patients.

This study shows that daptomycin resistance in Enterococcus faecium increased due to recurrent mutations and occasional transmission between patients in a hospital system.

Disease associated mutations in tau encode for changes in aggregate structure conformation

This study shows that disease-associated tau mutations alter the structure of tau aggregates, revealing new insights into their pathological mechanisms.

Decoupling of mRNA and protein expression in aging brains reveals the age-dependent adaptation of specific gene subsets

The paper examines mRNA and protein expression changes in aging mouse brains, finding age-dependent gene subset adaptations with distinct transcriptional and translational responses.

A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

The paper identifies CSA6 as a clade-specific cell cycle progression factor in Candida albicans, essential for mitotic exit and a potential antifungal target.

Immune Landscapes Predict Chemotherapy Resistance And Immunotherapy Response In Acute Myeloid Leukemia

This study identifies immune subtypes in AML and shows that IFN-gamma profiles predict chemotherapy resistance and immunotherapy response.

A Single Mechanosensitive Channel Protects Francisella tularensis subsp. holarctica from Hypoosmotic Shock and Promotes Survival in the Aquatic Environment.

This study identifies MscS as a mechanosensitive channel critical for Francisella tularensis subsp. holarctica survival in freshwater, enabling transmission between hosts.