Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells
A. V. Ward, D. Riley, K. E. Cosper, J. Finlay-Schultz, H. M. Brechbuhl, A. E. Libby, K. B. Hill, R. R. Varshney, P. Kabos, M. R. Rudolph, C. A. Sartorius
This study identifies lipid metabolic reprogramming in endocrine-resistant breast cancer cells, showing TVB-2640 reduces lipid storage but not cell growth.
bioRxiv · May 30, 2024Cancer Biology