L. Kennedy

Development of Scaffold-free 3D Cholangiocyte Organoids to Study the Progression of Primary Sclerosing Cholangitis

The paper develops scaffold-free 3D cholangiocyte organoids to study primary sclerosing cholangitis progression and confirms PSC-specific phenotypes.

Establishing Novel Doxorubicin-Loaded Polysaccharide Hydrogel for Controlled Drug Delivery for Treatment of Pediatric Brain Tumors

This paper develops a doxorubicin-loaded polysaccharide hydrogel for targeted drug delivery in pediatric brain tumors, showing sustained drug release and cytotoxicity against medulloblastoma cells.

Development of an In Vitro Test for the Optimization of Drug Diffusion in Pediatric Solid Tumors

This study develops an in vitro method to quantify drug diffusion through tumor tissue to optimize chemotherapy dosing for pediatric solid tumors and improve treatment outcomes.

Opposing diet, microbiome and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host

The paper shows that low dietary fiber promotes colitis in genetically susceptible mice by eroding mucus, while a fiber-free diet increases anti-inflammatory metabolites, highlighting microbial function over taxa in IBD regulation.

ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

This study shows ALKBH7 regulates glyoxal metabolism, and its deficiency protects against necrosis and ischemia-reperfusion injury through hormetic signaling involving methylglyoxal stress.