A. Jones

Investigating the impact of X-rays on decay: X-ray computed tomography as a non-invasive visualisation technique for sediment-based decay experiments

This study tests the impact of X-ray computed tomography (XCT) on decay of Danio rerio carcasses in sediment, finding no deviation in decay sequence and validating XCT as a non-destructive visualization method.

Improving reproductive success in captive marmosets through active female choice

This study improves breeding efficiency in captive marmosets by implementing a behavioral test allowing females to select mates, resulting in a 2.5-fold faster breeding success compared to random pairings.

Exploring the ageing methylome in the model insect,Nasonia vitripennis

This study investigates DNA methylation changes in Nasonia vitripennis during ageing, identifying age-related CpG methylation patterns and an epigenetic clock correlating with chronological age.

Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo.

Soil health increases primary productivity across Europe

This study links soil health to primary productivity across Europe's woodlands, grasslands, and croplands, showing higher soil health in woodlands and positive associations with productivity in croplands and grasslands.

Androgen receptor inhibition induces metabolic reprogramming and increased reliance on oxidative mitochondrial metabolism in prostate cancer

This study shows that androgen receptor inhibition in prostate cancer cells shifts metabolism to oxidative mitochondrial pathways and increases sensitivity to complex I inhibitors.

Molecular signatures of heat tolerance in an Australian alpine plant during moderate warming

This study examines the transcriptomic response of Wahlenbergia ceracea to sustained moderate warming, identifying gene regulation patterns linked to heat tolerance.

The three-dimensionally articulated oral apparatus of a Devonian heterostracan sheds light on feeding in Palaeozoic jawless fishes

This paper describes the feeding apparatus of a Devonian heterostracan, showing it was adapted for suspension/deposit feeding rather than active predation.

Bioinformatic and Experimental Characterization of the RBM15 RNA Binding Protein

This study characterizes RBM15's RNA binding mechanism through bioinformatics and experiments, showing it interacts with stem-loop RNA motifs via RRMs 2 and 3.

Anaerobic gut fungal communities in marsupial hosts

This study characterizes anaerobic gut fungal communities in marsupials, finding low abundance and lack of host-specific selection compared to placental herbivores.

Identification of Candidate Mitochondrial Inheritance Determinants Using the Mammalian Cell-Free System

The paper identifies 185 proteins differentially expressed in a porcine cell-free system related to post-fertilization sperm mitophagy, with six proteins further validated as potential cofactors in mitochondrial inheritance.

FcyRIIB is a novel immune checkpoint in the tumor microenvironment limiting activity of Treg-targeting antibodies

This paper identifies FcyRIIB as an inhibitory Fc receptor limiting Treg depletion by anti-CTLA-4 antibodies and shows Fc engineering can enhance their efficacy.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

Statistical challenges for inferring multiple SARS-CoV-2 spillovers with early outbreak phylodynamics

This paper challenges claims of multiple SARS-CoV-2 spillovers by showing methodological flaws in genome analysis and phylodynamic modeling.

Conformation and structural dynamics of the Xist lncRNA A-repeats

This study characterizes the conformational dynamics of Xist lncRNA A-repeats using an integrated approach of biochemical and biophysical techniques.

Development of an In Vitro Test for the Optimization of Drug Diffusion in Pediatric Solid Tumors

This study develops an in vitro method to quantify drug diffusion through tumor tissue to optimize chemotherapy dosing for pediatric solid tumors and improve treatment outcomes.

The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study

This study investigates the acute effects of CBD on emotional processing and anxiety using neuroimaging and cognitive measures, finding no significant effects compared to placebo.

Genomic constraints to drought adaptation

The paper uses genomic and climate data to identify adaptation constraints in Corymbia calophylla, finding that genetic diversity and epistatic interactions limit drought adaptation potential.

FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma

This study shows that FoxA1/2 are critical for tumorigenesis and cellular identity in NKX2-1-positive lung adenocarcinoma, with their loss impairing tumor growth and altering transcriptional programs.

The K18-hACE2 Transgenic Mouse Model Recapitulates Non-Severe and Severe COVID-19 in Response to Infectious Dose of SARS-CoV-2 Virus

The paper characterizes the K18-hACE2 mouse model's response to different SARS-CoV-2 doses, showing dose-dependent disease severity and recovery, and compares it to human COVID-19 pathology.

Individual and combined effects of Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) on striato-cortical connectivity in the human brain

This study examines how CBD and THC affect striato-cortical connectivity in the human brain using fMRI, finding THC disrupts connectivity while CBD mitigates some effects and has mixed impacts when used alone.

In vivo proteomic mapping through GFP-directed proximity dependent biotin labelling in zebrafish

The paper introduces a method to map protein interactions in zebrafish using GFP-directed biotin labelling and applies it to study caveolin interactors in muscle cells.

SETD2 regulates the methylation of translation elongation factor eEF1A1 in clear cell renal cell carcinoma

The paper investigates how SETD2 mutations in clear cell renal cell carcinoma affect protein methylation and translation, finding dysregulated translation linked to poor patient outcomes.

Targeting Vitamin-D receptor (VDR) by a small molecule antagonist MeTC7 inhibits PD-L1 but controls THMYCN neuroblastoma growth PD-L1 independently

This study shows that MeTC7, a VDR antagonist, reduces PD-L1 expression in cancer cells and inhibits neuroblastoma growth independently of PD-L1.

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

What makes Hemidactylus invasions successful? A case study on the island of Curacao.

This study investigates the factors contributing to the success of Hemidactylus mabouia invasions on Curaçao by analyzing diet, morphology, and competition with native geckos.

Global computational alignment of tumor and cell line transcriptional profiles

The paper develops an unsupervised alignment method to compare tumor and cell line transcriptional profiles, revealing differences in similarity across cancer types and identifying cell lines with distinct transcriptional states.

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

Septins disruption controls tumor growth and enhances efficacy of Herceptin

The paper develops UR214-9, a compound that disrupts septin filaments in cancer cells, inhibiting growth of HER2+ tumors and enhancing Herceptin efficacy.

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.