Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
F. Syed, O. Ballew, C.-C. Lee, J. Rana, P. Krishnan, A. Castela, S. A. Weaver, N. S. Chalasani, S. F. Thomaidou, S. Demine, G. Chang, A. Coomans de Brachene, M. I. Alvelos, L. Marselli, K. Orr, , C. Evans-Molina
This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.
bioRxiv · Mar 20, 2024Physiology