Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM
A. B. Loveland, E. Svidritskiy, D. Susorov, S. Lee, A. Park, G. Demo, F.-B. Gao, A. A. Korostelev
This study shows that poly-PR and poly-GR DPR proteins inhibit ribosome peptidyl-transferase activity by blocking the polypeptide tunnel, as revealed by cryo-EM structures.
bioRxiv · Aug 30, 2020Biochemistry