Author

A. B. Loveland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:cryo-EM· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. A. Korostelev· 3 shared E. Svidritskiy· 2 shared G. Demo· 2 shared A. Jacobson· 1 shared A. Park· 1 shared C. S. Koh· 1 shared C. Xu· 1 shared D. Susorov· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

A. A. Korostelev

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Author profile →

3 papers

Recent·Most cited

Structural mechanism of angiogenin activation by the ribosome

A. B. Loveland, C. S. Koh, R. Ganesan, A. Jacobson, A. A. Korostelev

This study identifies the ribosome as the activator of angiogenin, revealing how it enhances tRNA cleavage efficiency and ensures substrate specificity through structural rearrangements.

bioRxiv · Dec 11, 2023Biochemistry

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

A. B. Loveland, E. Svidritskiy, D. Susorov, S. Lee, A. Park, G. Demo, F.-B. Gao, A. A. Korostelev

This study shows that poly-PR and poly-GR DPR proteins inhibit ribosome peptidyl-transferase activity by blocking the polypeptide tunnel, as revealed by cryo-EM structures.

bioRxiv · Aug 30, 2020Biochemistry

Extensive ribosome and RF2 rearrangements during translation termination

E. Svidritskiy, G. Demo, A. B. Loveland, C. Xu, A. A. Korostelev

The paper visualizes the dynamic termination pathway of E. coli ribosomes with RF2 using cryo-EM, showing structural changes during protein release and RF2 dissociation.

bioRxiv · Apr 5, 2019Cell Biology