Author

E. Svidritskiy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:experimental assay· 3 Assay:cryo-EM· 2 Assay:structural biology· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. A. Korostelev· 3 shared G. Demo· 3 shared A. B. Loveland· 2 shared A. Korostelev· 1 shared A. Park· 1 shared C. Xu· 1 shared D. Sousa· 1 shared D. Susorov· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

A. A. Korostelev

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Author profile →

4 papers

Recent·Most cited

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

A. B. Loveland, E. Svidritskiy, D. Susorov, S. Lee, A. Park, G. Demo, F.-B. Gao, A. A. Korostelev

This study shows that poly-PR and poly-GR DPR proteins inhibit ribosome peptidyl-transferase activity by blocking the polypeptide tunnel, as revealed by cryo-EM structures.

bioRxiv · Aug 30, 2020Biochemistry

Extensive ribosome and RF2 rearrangements during translation termination

E. Svidritskiy, G. Demo, A. B. Loveland, C. Xu, A. A. Korostelev

The paper visualizes the dynamic termination pathway of E. coli ribosomes with RF2 using cryo-EM, showing structural changes during protein release and RF2 dissociation.

bioRxiv · Apr 5, 2019Cell Biology

Conformational control of translation termination on the 70S ribosome

E. Svidritskiy, A. A. Korostelev

The paper identifies a hyper-accurate RF1 variant and presents crystal structures showing how RF1 structural dynamics coordinate stop-codon recognition with peptide release during translation termination.

bioRxiv · Nov 29, 2017Biochemistry

Mechanism of ribosome rescue by ArfA and RF2

G. Demo, E. Svidritskiy, R. Madireddy, R. Diaz-Avalos, T. Grant, N. Grigorieff, D. Sousa, A. Korostelev

This study reveals the structural dynamics of ribosome rescue by ArfA and RF2, showing how ArfA activates RF2 to release peptides from stalled ribosomes without a stop codon.

eLife · Mar 16, 2017Peer-reviewedBiochemistry