Author

G. Demo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Research Focus:protein structure prediction· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

E. Svidritskiy· 3 shared A. A. Korostelev· 2 shared A. B. Loveland· 2 shared B. A. Kelch· 2 shared A. Korostelev· 1 shared A. Park· 1 shared C. Gaubitz· 1 shared C. Xu· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

E. Svidritskiy

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Author profile →

5 papers

Recent·Most cited

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

C. Gaubitz, X. Liu, J. Pajak, N. P. Stone, J. A. Hayes, G. Demo, B. A. Kelch

The paper presents cryo-EM structures of the yeast clamp loader RFC bound to PCNA, revealing the mechanism of clamp opening and DNA binding without ATP hydrolysis.

bioRxiv · Sep 23, 2021Biochemistry

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

A. B. Loveland, E. Svidritskiy, D. Susorov, S. Lee, A. Park, G. Demo, F.-B. Gao, A. A. Korostelev

This study shows that poly-PR and poly-GR DPR proteins inhibit ribosome peptidyl-transferase activity by blocking the polypeptide tunnel, as revealed by cryo-EM structures.

bioRxiv · Aug 30, 2020Biochemistry

Extensive ribosome and RF2 rearrangements during translation termination

E. Svidritskiy, G. Demo, A. B. Loveland, C. Xu, A. A. Korostelev

The paper visualizes the dynamic termination pathway of E. coli ribosomes with RF2 using cryo-EM, showing structural changes during protein release and RF2 dissociation.

bioRxiv · Apr 5, 2019Cell Biology

Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure

N. Stone, G. Demo, E. Agnello, B. A. Kelch

The paper determines the structure of a thermostable virus capsid and identifies structural features that enhance stability and capacity.

bioRxiv · Jan 5, 2019Biochemistry

Mechanism of ribosome rescue by ArfA and RF2

G. Demo, E. Svidritskiy, R. Madireddy, R. Diaz-Avalos, T. Grant, N. Grigorieff, D. Sousa, A. Korostelev

This study reveals the structural dynamics of ribosome rescue by ArfA and RF2, showing how ArfA activates RF2 to release peptides from stalled ribosomes without a stop codon.

eLife · Mar 16, 2017Peer-reviewedBiochemistry