Defining the Substrate Envelope of SARS-CoV-2 Main Protease to Predict and Avoid Drug Resistance
A. M. Shaqra, S. Zvornicanin, Q. Y. Huang, G. J. Lockbaum, M. Knapp, L. Tandeske, D. T. Barkan, J. Flynn, D. N. Bolon, S. Moquin, D. Dovala, N. Kurt Yilmaz, C. A. Schiffer
This study defines the substrate envelope of SARS-CoV-2 main protease using cocrystal structures to identify vulnerable sites that may lead to drug resistance.
bioRxiv · Jan 25, 2022Biochemistry