Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation
J. M. Flynn, M. E. Joyce, D. N. Bolon
bioRxiv · Jan 2, 2024 · PreprintBiochemistry
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J. M. Flynn, M. E. Joyce, D. N. Bolon
bioRxiv · Jan 2, 2024 · PreprintBiochemistry
A. M. Shaqra, S. Zvornicanin, Q. Y. Huang, G. J. Lockbaum, M. Knapp, L. Tandeske, D. T. Barkan, J. Flynn, D. N. Bolon, S. Moquin, D. Dovala, N. Kurt Yilmaz, C. A. Schiffer
This study defines the substrate envelope of SARS-CoV-2 main protease using cocrystal structures to identify vulnerable sites that may lead to drug resistance.
bioRxiv · Jan 25, 2022Biochemistry