Author

G. J. Lockbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

C. A. Schiffer· 2 shared A. Ali· 1 shared A. M. Shaqra· 1 shared A. Sondgeroth· 1 shared D. Dovala· 1 shared D. N. Bolon· 1 shared D. T. Barkan· 1 shared E. Nalivaika· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

C. A. Schiffer

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Selection of HIV-1 for Resistance to Fifth Generation Protease Inhibitors Reveals Two Independent Pathways to High-Level Resistance

E. Spielvogel, S.-K. Lee, S. Zhou, G. J. Lockbaum, M. Henes, A. Sondgeroth, K. Kosovrasti, E. Nalivaika, A. Ali, N. K. Yilmaz, C. A. Schiffer, R. Swanstrom

This study identifies two independent resistance pathways to fifth-generation protease inhibitors in HIV-1 by analyzing mutations under high drug concentrations.

bioRxiv · Jun 23, 2022Microbiology

Defining the Substrate Envelope of SARS-CoV-2 Main Protease to Predict and Avoid Drug Resistance

A. M. Shaqra, S. Zvornicanin, Q. Y. Huang, G. J. Lockbaum, M. Knapp, L. Tandeske, D. T. Barkan, J. Flynn, D. N. Bolon, S. Moquin, D. Dovala, N. Kurt Yilmaz, C. A. Schiffer

This study defines the substrate envelope of SARS-CoV-2 main protease using cocrystal structures to identify vulnerable sites that may lead to drug resistance.

bioRxiv · Jan 25, 2022Biochemistry