Author

L. Tandeske

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

D. Dovala· 2 shared M. Knapp· 2 shared A. M. Shaqra· 1 shared C. A. Schiffer· 1 shared C. C. Ward· 1 shared C. M. Zammit· 1 shared D. Fuller· 1 shared D. K. Nomura· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

D. Dovala

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors

P. Moon, L. Boike, D. Dovala, N. J. Henning, M. Knapp, J. N. Spradlin, C. C. Ward, H. Wolleb, C. M. Zammit, D. Fuller, G. Blake, J. P. Murphy, F. Wang, Y. Lu, S. A. Moquin, , D. K. Nomura

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

bioRxiv · Mar 5, 2022Biochemistry

Defining the Substrate Envelope of SARS-CoV-2 Main Protease to Predict and Avoid Drug Resistance

A. M. Shaqra, S. Zvornicanin, Q. Y. Huang, G. J. Lockbaum, M. Knapp, L. Tandeske, D. T. Barkan, J. Flynn, D. N. Bolon, S. Moquin, D. Dovala, N. Kurt Yilmaz, C. A. Schiffer

This study defines the substrate envelope of SARS-CoV-2 main protease using cocrystal structures to identify vulnerable sites that may lead to drug resistance.

bioRxiv · Jan 25, 2022Biochemistry