Multiplexed Single Ion Mass Spectrometry Improves Measurement of Proteoforms and Their Complexes
J. O. Kafader, R. D. Melani, K. R. Durbin, B. Ikwuagwu, B. P. Early, R. T. Fellers, S. C. Beu, V. Zabrouskov, A. A. Makarov, J. T. Maze, D. L. Shinholt, P. F. Yip, D. Tullman-Ereck, M. W. Senko, P. D. Compton, N. L. Kelleher
This paper introduces a new Orbitrap-based single ion analysis method that improves the measurement of proteoforms and their complexes by directly determining ion charge.
bioRxiv · Jul 26, 2019 · PreprintBiochemistry