Author

R. D. Melani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

N. L. Kelleher· 3 shared J. P. McGee· 2 shared A. A. Makarov· 1 shared B. Ikwuagwu· 1 shared B. P. Early· 1 shared D. L. Shinholt· 1 shared D. Tullman-Ereck· 1 shared J. O. Kafader· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

N. L. Kelleher

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3 papers

Recent·Most cited

Standard Procedures for Native CZE-MS of Proteins and Protein Complexes up to 800 kDa

K. Jooss, J. P. McGee, R. D. Melani, N. L. Kelleher

The paper provides standard operating procedures for native capillary electrophoresis mass spectrometry (nCZE-MS) to improve reproducibility and data quality for large proteins and complexes.

bioRxiv · Nov 2, 2020Biochemistry

Multiplexed Single Ion Mass Spectrometry Improves Measurement of Proteoforms and Their Complexes

J. O. Kafader, R. D. Melani, K. R. Durbin, B. Ikwuagwu, B. P. Early, R. T. Fellers, S. C. Beu, V. Zabrouskov, A. A. Makarov, J. T. Maze, D. L. Shinholt, P. F. Yip, D. Tullman-Ereck, M. W. Senko, P. D. Compton, N. L. Kelleher

This paper introduces a new Orbitrap-based single ion analysis method that improves the measurement of proteoforms and their complexes by directly determining ion charge.

bioRxiv · Jul 26, 2019 · PreprintBiochemistry

Direct Measurement of Light and Heavy Antibody Chains Using Differential Ion Mobility Spectrometry and Middle-Down Mass Spectrometry

R. D. Melani, K. Srzentic, V. R. Gerbasi, J. P. McGee, R. Huguet, L. Fornelli, N. L. Kelleher

This paper introduces a rapid FAIMS tandem MS method for characterizing monoclonal antibody light and heavy chains, reducing analysis time by 40-60% compared to LC-MS/MS.

bioRxiv · Jul 5, 2019Biochemistry